![]() ![]() ![]() This is rapidly detoxified by conjugation with hepatic glutathione and excreted in urine. Patients with chronic liver disease who do not regularly ingest alcohol do not appear to be at increased risk for acetaminophen-induced hepatic injury.Ī fraction of paracetamol is metabolized by the hepatic cytochrome P450 pathway to toxic N-acetyl-p-benzoquinoneimine (NAPQI). ![]() Hepatic enzyme inducing drugs- phenytoin, rifampicin, carbamazepine, barbiturates, primidone.Chronic high alcohol consumption (>21 U in males and 14U in females).eating disorder, cystic fibrosis, AIDS (causes glutathione depletion) High risk patients (>7.5g may produce toxicity): Establishment of Gastrointestinal Endoscopy AreasĪt least 12g paracetamol is usually required to produce serious toxicity in adults, unless the patient is at high risk.Iron Replacement (parenteral dosing) for Iron Deficiency. ![]()
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